Here's my thought of the day (spoilered because it relates to a show I watch that others may not have seen):
Spoiler - click to show.
In Jojo's Bizarre Adventure: Golden Wind (Part 5), Diavolo dies an infinite amount of deaths. In any of those alternate timelines, we human beings could have been a result of one of Diavolo's many deaths, therefore making our existences as a whole, a Jojo reference.